Abstract: Objective To investigate the effect of laparoscopic guided regional nerve block of bilateral uterosacral ligaments on postoperative analgesia and early rehabilitation of patients undergoing laparoscopic myo⁃ mectomy. Methods 70 patients scheduled for elective laparoscopic myomectomy under general anesthesia were randomly divided into two groups with 35 patients in each group. The observation group performed after general an⁃ esthesia combined with nerve block in bilateral uterosacral ligament region，andthe control group performed after general anesthesia. The amount of anesthetic used during the operation，the VAS pain score at different time points after the operation，the recovery time of intestinal function after the operation，the time of immobility，and the 15 quality of recovery（QoR ⁃ 15）scores 24 hours after the operation were recorded. The total amount of analgesics used，the recovery rate of analgesia and the occurrence of related adverse reactions were recorded. Results Com⁃ pared with control group，the intraoperative consumption of remifentanil was significantly reduced（P < 0.05），and the VAS pain score of 2 hours after operation in the observation group was lower（P < 0.05）. The QoR⁃15 score at 24 hours after the operation were significantly increased（P < 0.05），and the analgesic dosage，analgesic salvage rate，and the incidence of nausea and vomiting were significantly reduced in the observation group within 24 hours after surgery（P < 0.05）. Conclusion Laparoscopic guided regional nerve block of bilateral uterosacral ligaments can reduce the perioperative opioid dosage of patients with laparoscopic myomectomy，reduce postoperative pain，re⁃ duce postoperative complications，and improve the quality of postoperative recovery. 

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